This retrospective study looked at the role of tranexamic acid in paediatric trauma - it was a study conducted out of Camp Bastion in Afghanistan.
There were 766 patients enrolled in the trial with 9% of patients recieving tranexamic acid. Tranexamic acid was most commonly given in severe abdominal trauma or extremity trauma.
Most of the trauma was penetrating (73%) with 35% recieving a blood transfusion and 10% recieving a massive transfusion.
Patients were given a single loading dose of tranexamic acid (standard adult dose of 1g) - ensuing infusions were at the discretion of the physician.
Overall mortality was reduced with no significant difference in thromboembolic rates.
This data reflects the findings in the adult literature that tranexamic acid is safe and effective in paediatric trauma.
- Eckert M et al. Tranexamic acid administration to paediatric trauma patients in a combat setting: The paediatric trauma and tranexamic acid study (PED-TRAX). J Trauma Acute Care Surg. 2014;77(6);852-858.